MOTS-c

Mitochondrial-derived peptide encoded within the 12S rRNA, studied for effects on cellular energy metabolism, glucose homeostasis, and exercise capacity in research models.

MOTS-c (Mitochondrial Open Reading frame of the Twelve S rRNA-c) is a 16-amino-acid peptide encoded not in the nucleus but within the mitochondrial 12S ribosomal RNA gene. It is one of the few characterised mitochondrially-encoded peptides and has become a focus of research into metabolic regulation, AMPK signalling, and exercise physiology. Quantum Labs supplies MOTS-c as a lyophilised powder for Australian research applications.

MOTS-c research has covered models of glucose homeostasis, insulin sensitivity, fatty-acid oxidation, and exercise capacity. The compound is studied as a putative regulator of metabolic flexibility through AMPK activation. Material is HPLC-verified to ≥99% purity and ships from Australian stock; supplied for laboratory research use only.

Research Mechanism

Research suggests AMPK pathway activation, with associated effects on glucose uptake, fatty acid oxidation, and mitochondrial biogenesis markers in study subjects.